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Penile carcinoma in patients with genital lichen sclerosus: a multicenter survey.
uretra, lichen Sclerosus
Barbagli G, Palminteri
E, Mirri F, Guazzoni G, Turini D, Lazzeri M.
Penile carcinoma in patients with genital
lichen sclerosus: a multicenter survey.
J Urol.
2006 Apr;175(4):1359-63.
Keywords:uretra,lichen sclerosus
PURPOSE: In this
observational descriptive study we reviewed the histology and the clinical
records of 130 patients with LS involving the male genitalia to determine the
presence of premalignant or malignant lesions.
MATERIALS AND METHODS: A total
of 130 male patients (from 1991 to 2001) with genital LS were treated at our
centers. Mean patient age at diagnosis was 42.5 years. In all patients with a
clinical diagnosis of LS, the histology was reexamined to look for evidence of LS,
applying strict histological criteria. All cases of histologically proven
epithelial malignancy, namely SCC, VC and EQ, were reviewed to confirm the
presence of neoplastic changes and ascertain the degree of SCC differentiation.
RESULTS: Of 130 men 11 (8.4%) with genital LS showed premalignant or malignant
histopathological features including 7 (64%) with SCC, 2 (18%) with VC, 1 (9%)
with EQ and 1 (9%) with SCC associated with VC. In 6 of 11 patients (55%) the
histological study showed the presence of epithelial dysplasia.
CONCLUSIONS:
Survival of patients with penile carcinoma depends on early diagnosis and
treatment, and all patients with genital LS should be observed closely to
detect the development of neoplastic or preneoplastic lesions as early as possibile.
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